Review Article

Infection-Related Focal Segmental Glomerulosclerosis in Children

Table 1

Causes for secondary FSGS.

GroupExamples

InfectionsHIV
Parvovirus B19
CMV

DrugsHeroine
Bisphosphonate
Calcineurin inhibitors and mTor inhibitors
Interferon

Prenatal risk factorsVery low birth weight
Intrauterine growth retardation

Life styleObesity
Anabolic steroids

Reduction in nephron massResection
Trauma

Tubulointerstitial injuryReflux nephropathy
Dent’s disease
Lowe syndrome

Systemic diseasesPlasma cell dyscrasias
Weber-Christian Disease

Genetic mutationsNephrin
Podocin
CD2AP
WT1
Laminin β2
Alpha-actinin 4