NALP3-Inflammasome-Related Gene Polymorphisms in Patients with Prehypertension and Coronary Atherosclerosis
Table 4
Genotypes and allele frequencies of NLRP3 and CARD8 SNP polymorphisms among prehypertensive patients.
Genotype SNPs
Allele
Genotype (stenosis < 50%)
Genotype (stenosis ≥ 50%)
Allele A versus B
AA versus BB
BB versus AB
A
B
AA (%)
AB (%)
BB (%)
AA (%)
AB (%)
BB (%)
OR (95% CI)
value
Bonf-p
OR (95% CI)
value
Bonf-p
OR (95% CI)
value
Bonf-p
CARD8
rs10403848
G
A
139 (49.47)
114 (40.57)
28 (9.96)
135 (45.76)
132 (44.75)
28 (9.49)
0.193
1.072 (0.787–1.461)
0.661
1.000
1.006 (0.703–1.438)
0.976
1.000
1.182 (0.736–1.898)
0.488
1.000
NLRP3
rs4612666
C
T
86 (30.61)
145 (51.60)
50 (17.80)
98 (33.22)
145 (49.15)
52 (17.63)
0.178
0.780 (0.585–1.038)
0.673
1.000
0.950 (0.704–1.281)
0.734
1.000
0.922 (0.610–1.392)
0.698
1.000
rs1539019
C
T
68 (24.20)
143 (50.89)
70 (24.91)
79 (26.78)
170 (57.63)
46 (15.59)
2.920
1.576 (1.152–2.155)
0.090
1.000
0.743 (0.547–1.008)
0.056
0.840
1.372 (0.910–2.039)
0.132
0.588
rs10754558
C
G
63 (22.42)
138 (49.11)
80 (28.47)
90 (30.51)
138 (46.78)
67 (22.71)
3.569
0.759 (0.570–1.011)
0.060
0.900
0.767 (0.580–1.017)
0.066
0.990
0.906 (0.603–1.361)
0.635
1.000
rs10925027
C
T
92 (32.74)
131 (46.62)
58 (20.64)
70 (23.73)
151 (51.19)
74 (25.08)
3.212
1.3 (0.976–1.732)
0.073
1.000
1.284 (0.964–1.710)
0.088
1.000
1.184 (0.787–1.779)
0.418
1.000
SNP: single nucleotide polymorphism; CI: confidence interval; OR: odds ratio. Bonf-p: value with Bonferroni correction. Allele A is the wild-type allele.
