Partial Portal Vein Arterialization Attenuates Acute Bile Duct Injury Induced by Hepatic Dearterialization in a Rat Model

Figure 3

BDI-induced bile duct injury. Representative gross photographs of (a) bile leakage and (b) biloma formation after BDI. (c) Hematoxylin and eosin (H&E) staining shows desquamated biliary epithelium (arrows), biliary casts (asterisk), and fibrosis (arrowheads) 14 days after the surgery (magnification, 100x). (d) Biliary casts (asterisk) were also detected in the lumen of the cannulation tube (arrowheads). Cholangiocyte vacuolization was observed (arrows; H&E staining, magnification, 400x). (e) PPVA improved partial pressure of oxygen of the portal vein. (f) PPVA ameliorated BDI-induced ATP depletion. Data are expressed as mean ± SEM (6 rats per group). versus the Sham group; versus the PPVA + BDI group. Differences were assessed by two-way ANOVA and comparisons between groups were performed by Bonferroni posttests at each time point.

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