MicroRNA Profiling in Patients with Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy

Table 3

Pathway analysis of BEN-UTUC differentially expressed microRNAs based on miRNA targets predicted in DIANA-microT-CDS v.5.0.

KEGG pathway	P value	Number of genes	Genes	Number of miRNAs	miRNAs
Mucin type O-glycan biosynthesis (hsa00512)		8	GALNT7, GALNT8, GCNT3, GALNT1, GALNT3, GALNT10, GALNT2, GCNT1	2	hsa-miR-3620-3p; hsa-miR-30a-5p
ECM-receptor interaction (hsa04512)		5	THBS1, COL24A1, COL27A1, CD47, COL4A1	1	hsa-miR-3620-3p
Morphine addiction (hsa05032)	0.008499588	17	PRKCA, GNG12, DRD1, PDE4D, PDE1A, GNG10, GABRA5, GNG2, KCNJ6, GABRB1, GNAI2, PDE7A, ADCY9, GNB4, KCNJ3, GABRA2, PRKACB	2	hsa-miR-373-5p; hsa-miR-30a-5p
Hippo signaling pathway (hsa04390)	0.01475759	16	YAP1, BMPR1B, FZD6, WWC1, AMOT, PPP2R2D, TP53BP2, FZD3, CDH1, SMAD4, AXIN2, NKD1, RASSF6, DLG2, SMAD1, INADL	1	hsa-miR-205-5p
Glycosphingolipid biosynthesis-lacto and neolacto series (hsa00601)	0.02886044	3	FUT1, ST3GAL6, FUT9	1	hsa-miR-205-5p

KEGG: Kyoto Encyclopedia of Genes and Genomes; ECM: extracellular matrix.