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BioMed Research International
Volume 2016, Article ID 7461047, 8 pages
Review Article

Experimental Models of Oral Biofilms Developed on Inert Substrates: A Review of the Literature

1Université de Bordeaux, 16 Cours de la Marne, 33082 Bordeaux, France
2ISVV, EA 4577 Unité de Recherche Oenologie, Institut Polytechnique de Bordeaux, Université de Bordeaux, 33140 Villenave d’Ornon, France

Received 3 July 2016; Accepted 14 August 2016

Academic Editor: Aruni Wilson

Copyright © 2016 Lopez-Nguyen Darrene and Badet Cecile. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The oral ecosystem is a very complex environment where more than 700 different bacterial species can be found. Most of them are organized in biofilm on dental and mucosal surfaces. Studying this community is important because a rupture in stability can lead to the preeminence of pathogenic microorganisms, causing dental decay, gingivitis, or periodontitis. The multitude of species complicates biofilm analysis so its reproduction, collection, and counting are very delicate. The development of experimental models of dental biofilms was therefore essential and multiple in vitro designs have emerged, each of them especially adapted to observing biofilm formation of specific bacteria within specific environments. The aim of this review is to analyze oral biofilm models.