Identification of Novel RD1 Antigens and Their Combinations for Diagnosis of Sputum Smear−/Culture+ TB Patients

Table 2

Diagnostic performance of five antigen combinations. The positive detection was defined as positive with different number of antigens as shown.

Positive antigens		One		Two		Three		Four		Five
		+	−	+	−	+	−	+	−	+	−
TB	298	288	10	259	39	210	88	146	152	56	242
Control	95	41	54	18	77	10	85	1	94	0	95
Sensitivity		96.64%		86.91%		70.47%		48.99%		18.79%
Specificity		56.84%		81.05%		89.47%		98.95%		100%
Youden		0.5348		0.6796		0.5994		0.4794		0.1879
PPV		87.54%		93.50%		95.45%		99.32%		100%
NPV		84.38%		66.38%		49.13%		38.21%		28.19%

indicates the least number of antigens defined for positive detection.