Identification of Novel RD1 Antigens and Their Combinations for Diagnosis of Sputum Smear−/Culture+ TB Patients

Table 3

Diagnostic performance of combinations of 4 antigens. The positive detection was defined as positive with at least two antigens.

Combined antigens		Rv71-74-75-76		Rv71-74-75-79		Rv71-74-76-79		Rv71-75-76-79		Rv74-75-76-79
		+	−	+	−	+	−	+	−	+	−
TB	298	224	74	244	54	255	43	243	55	228	70
Control	95	10	85	10	85	16	79	11	84	11	84
Sensitivity		75.17%		82.71%		86.44%		82.37%		77.29%
Specificity		89.47%		89.47%		83.06%%		88.42%		88.42%
Youden		0.6464		0.7218		0.6950		0.7079		0.6571
PPV		95.73%		96.06%		94.1%		95.67%		95.4%
NPV		53.46%		61.15%		64.75%		60.43%		54.55%

Rv71-74-75-76 represents the combination of Rv3871, Rv3874, Rv3875, and Rv3876 for TB diagnosis. The other combinations are also abbreviated including Rv71-74-75-79, Rv71-74-76-79, Rv71-74-76-79, Rv71-75-76-79, and Rv74-75-76-79.