Table 3: Diagnostic performance of combinations of 4 antigens. The positive detection was defined as positive with at least two antigens.

Combined antigensRv71-74-75-76Rv71-74-75-79Rv71-74-76-79Rv71-75-76-79Rv74-75-76-79

+++++

TB2982247424454255432435522870
Control9510851085167911841184

Sensitivity75.17%82.71%86.44%82.37%77.29%
Specificity89.47%89.47%83.06%%88.42%88.42%
Youden0.64640.72180.69500.70790.6571
PPV95.73%96.06%94.1%95.67%95.4%
NPV53.46%61.15%64.75%60.43%54.55%

Rv71-74-75-76 represents the combination of Rv3871, Rv3874, Rv3875, and Rv3876 for TB diagnosis. The other combinations are also abbreviated including Rv71-74-75-79, Rv71-74-76-79, Rv71-74-76-79, Rv71-75-76-79, and Rv74-75-76-79.