Identification of Novel RD1 Antigens and Their Combinations for Diagnosis of Sputum Smear−/Culture+ TB Patients

Table 4

Diagnostic performance of combinations of 3 antigens. The positive detection was defined as positive with at least two antigens.

Combined antigens		TB	Control	Sensitivity	Specificity	Youden	PPV	NPV
		298	95
Rv71-76-79	+	237	9	79.53%	90.53%	0.7006	96.34%	58.5%
	−	61	86
Rv71-75-79	+	222	10	74.5%	89.47%	0.6397	95.69%	52.8%
	−	76	85
Rv71-75-76	+	187	10	62.75%	89.47%	0.5222	94.92%	43.37%
	−	111	85
Rv71-74-79	+	239	11	80.20%	88.42%	0.6862	95.6%	58.74%
	−	59	84
Rv71-74-76	+	216	12	72.48	87.37%	0.5985	94.74%	50.3%
	−	82	83
Rv71-74-75	+	189	6	63.42%	93.68%	0.5710	96.92%	44.95%
	−	109	89
Rv75-76-79	+	192	9	64.43%	90.53%	0.5496	95.52%	44.79%
	−	106	86
Rv74-76-79	+	224	13	75.93%	86.32%	0.6225	94.51%	52.56%
	−	74	82
Rv74-75-79	+	186	3	62.42%	96.84%	0.5926	98.41%	45.1%
	−	112	92
Rv74-75-76	+	164	4	55.03%	95.79%	0.5082	97.62%	40.44%
	−	134	91