Identification of Novel RD1 Antigens and Their Combinations for Diagnosis of Sputum Smear−/Culture+ TB Patients

Table 5

Diagnostic performance of the combination of Rv3871, Rv3876, and Rv3879 in different TB populations. The positive detection was defined as positive with at least two antigens.

		Pos.	Neg.	Sensitivity	Specificity	Youden	PPV	NPV
S+/C+	117	89	28	76.07%	90.53%	0.6660	90.81%	75.43%
S−/C+	80	68	12	85%	90.53%	0.7553	88.3%	87.76%
S−/C−	101	80	21	79.21%	90.53%	0.6974	89.89%	80.37%
Control	95	9	86

S+/−: sputum smear +/− TB, C+/−: sputum culture +/− TB, Pos.: positive, Neg.: negative.