Physiological Study on Association between Nicotinamide N-Methyltransferase Gene Polymorphisms and Hyperlipidemia
Table 2
Frequency distributions of the hyperlipidemia cases and controls.
SNPs
Allele
P
Genotype
HWE
P
rs2511153
Case
C: 525 (0.68)
T: 253 (0.33)
0.035
CC: 172 (0.44)
CT: 181 (0.47)
TT: 36 (0.09)
0.095
Ctrl
C: 390 (0.62)
T: 238 (0.38)
CC: 116 (0.37)
CT: 158 (0.50)
TT: 40 (0.13)
0.22
rs505978
Case
A: 443 (0.59)
G: 309 (0.41)
0.067
AA: 131 (0.35)
AC: 181 (0.48)
CC: 64 (0.17)
0.115
Ctrl
A: 338 (0.54)
G: 288 (0.46)
AA: 86 (0.28)
AC: 166 (0.53)
CC: 61 (0.20)
0.23
rs694539
Case
A: 262 (0.35)
G: 494 (0.65)
0.665
AA: 54 (0.14)
AG: 154 (0.41)
GG: 170 (0.45)
0.005
Ctrl
A: 210 (0.34)
G: 416 (0.67)
AA: 25 (0.08)
AG: 160 (0.51)
GG: 128 (0.41)
0.01
rs12285641
Case
C: 457 (0.58)
T: 325 (0.42)
0.090
CC: 139 (0.36)
CT: 179 (0.46)
TT: 73 (0.19)
0.010
Ctrl
C: 390 (0.63)
T: 230 (0.37)
CC: 113 (0.37)
CT: 164 (0.53)
TT: 33 (0.11)
0.02
rs11214926
Case
A: 242 (0.32)
G: 514 (0.68)
0.013
AA: 48 (0.13)
AG: 146 (0.39)
GG: 184 (0.49)
0.001
Ctrl
A: 162 (0.26)
G: 464 (0.74)
AA: 12 (0.04)
AG: 138 (0.44)
GG: 163 (0.52)
0.01
rs7109984
Case
C: 680 (0.87)
T: 102 (0.13)
0.652
CC: 290 (0.74)
CT: 100 (0.26)
TT: 1 (0.00)
0.271
Ctrl
C: 534 (0.86)
T: 86 (0.14)
CC: 228 (0.74)
CT: 78 (0.25)
TT: 4 (0.01)
0.35
rs10891644
Case
G: 509 (0.65)
T: 269 (0.35)
0.109
GG: 158 (0.41)
GT: 193 (0.50)
TT: 38 (0.10)
0.011
Ctrl
G: 428 (0.70)
T: 188 (0.31)
GG: 155 (0.50)
GT: 118 (0.38)
TT: 35 (0.11)
0.09
rs55675450
Case
A: 119 (0.15)
G: 659 (0.85)
0.976
AA: 13 (0.03)
AG: 93 (0.24)
GG: 283 (0.73)
0.987
Ctrl
A: 96 (0.15)
G: 534 (0.85)
AA: 11 (0.04)
AG: 74 (0.24)
GG: 230 (0.73)
0.11
rs2244175
Case
A: 404 (0.53)
G: 352 (0.47)
0.117
AA: 103 (0.27)
AG: 198 (0.52)
GG: 77 (0.20)
0.115
Ctrl
A: 308 (0.49)
G: 318 (0.51)
AA: 64 (0.20)
AG: 180 (0.58)
GG: 69 (0.22)
0.01
rs2847492
Case
A: 264 (0.35)
G: 492 (0.65)
0.882
AA: 51 (0.14)
AG: 162 (0.43)
GG: 165 (0.44)
0.179
Ctrl
A: 221 (0.35)
G: 405 (0.65)
AA: 33 (0.11)
AG: 155 (0.50)
GG: 125 (0.40)
0.14
rs2852432
Case
C: 399 (0.53)
T: 357 (0.47)
0.022
CC: 101 (0.27)
CT: 197 (0.52)
TT: 80 (0.21)
0.051
Ctrl
C: 369 (0.59)
T: 257 (0.41)
CC: 102 (0.33)
CT: 165 (0.53)
TT: 46 (0.15)
0.11
rs4646335
Case
A: 487 (0.64)
T: 269 (0.36)
0.011
AA: 161 (0.43)
AT: 165 (0.44)
TT: 52 (0.14)
0.004
Ctrl
A: 360 (0.58)
T: 264 (0.42)
AA: 95 (0.30)
AT: 170 (0.55)
TT: 47 (0.15)
0.04
rs3819100
Case
A: 431 (0.57)
G: 325 (0.43)
0.005
AA: 120 (0.32)
AG: 191 (0.51)
GG: 67 (0.18)
0.012
Ctrl
A: 309 (0.49)
G: 317 (0.51)
AA: 70 (0.22)
AG: 169 (0.54)
GG: 74 (0.24)
0.16
rs2256292
Case
C: 327 (0.43)
G: 439 (0.57)
0.053
CC: 71 (0.19)
CG: 185 (0.48)
GG: 127 (0.33)
0.063
Ctrl
C: 236 (0.38)
G: 392 (0.62)
CC: 38 (0.12)
CG: 160 (0.51)
GG: 116 (0.37)
0.13
rs2301128
Case
A: 100 (0.13)
G: 678 (0.87)
0.739
AA: 9 (0.02)
AG: 82 (0.21)
GG: 298 (0.77)
0.924
Ctrl
A: 77 (0.12)
G: 551 (0.88)
AA: 6 (0.02)
AG: 65 (0.21)
GG: 243 (0.77)
0.50
rs1941404
Case
C: 391 (0.53)
T: 349 (0.47)
0.000
CC: 117 (0.32)
CT: 157 (0.42)
TT: 96 (0.26)
0.000
Ctrl
C: 268 (0.43)
T: 358 (0.57)
CC: 50 (0.16)
CT: 168 (0.54)
TT: 95 (0.30)
0.09
rs2155806
Case
C: 78 (0.10)
T: 700 (0.90)
0.346
CC: 7 (0.01)
CT: 64 (0.17)
TT: 318 (0.82)
0.322
Ctrl
C: 73 (0.12)
T: 557 (0.88)
CC: 4 (0.01)
CT: 65 (0.21)
TT: 246 (0.78)
0.90
rs1941399
Case
A: 119 (0.16)
C: 637 (0.84)
0.550
AA: 7 (0.02)
AC: 105 (0.28)
CC: 266 (0.70)
0.525
Ctrl
A: 106 (0.17)
C: 520 (0.83)
AA: 10 (0.03)
AC: 86 (0.28)
CC: 217 (0.69)
0.68
rs4646337
Case
A: 680 (0.88)
G: 94 (0.12)
0.748
AA: 296 (0.77)
AG: 88 (0.23)
GG: 3 (0.01)
0.250
Ctrl
A: 557 (0.88)
G: 73 (0.12)
AA: 248 (0.79)
AG: 61 (0.19)
GG: 6 (0.02)
0.33
Case, the hyperlipidemia group; Ctrl, the control group; HWE, value of Hardy-Weinberg equilibrium test on the control group; the values of allele and genotype are the number of individuals (frequency).
