Human Ribosomal RNA-Derived Resident MicroRNAs as the Transmitter of Information upon the Cytoplasmic Cancer Stress

Table 1

Detected mature miRNAs from rRNA gene and adjacent region.

miR name	Mature sequence	Region	Location
miR-663a	AGGCGGGGCGCCGCGGGACCGC	5′ ETS	2049–2071
miR-663b	GGUGGCCCGGCCGUGCCUGAGG	5′ ETS	2113–2135
miR-1268a	CGGGCGUGGUGGUGGGGG	3′ ETS	13102–13119
miR-1268b	CGGGCGUGGUGGUGGGGGUG	3′ ETS	13102–13121
miR-1275	GUGGGGGAGAGGCUGUC	(NTS)	42294–42310
miR-3648	AGCCGCGGGGAUCGCCGAGGG	5′ ETS	2513–2533
miR-3656	GGCGGGUGCGGGGGUGG	28S	8524–8540
miR-3687	CCCGGACAGGCGUUCGUGCGACGU	(5′ ETS)	2888–2911
miR-4417	GGUGGGCUUCCCGGAGGG	5′ ETS	2412–2429
miR-4466	GGGUGCGGGCCGGCGGGG	(5′ ETS)	631–648
miR-4488	AGGGGGCGGGCUCCGGCG	28S	8510–8527
miR-4492	GGGGCUGGGCGCGCGCC	28S	10851–10867
miR-4508	GCGGGGCUGGGCGCGCG	28S	10849–10865
miR-4516	GGGAGAAGGGUCGGGGC	28S	11049–11065
miR-4532	CCCCGGGGAGCCCGGCG	28S	11227–11243
miR-6087	UGAGGCGGGGGGGCGAGC	28S	12007–12024
miR-6724	CUGGGCCCGCGGCGGGCGUGGGG	(NTS)	42320–42342

Seventeen sequences homologous to mature human miRNAs were detected from rRNA gene coding region. Note that miR-1268a and miR-1268b were found in only RNA45S and miR-1275, miR-3687, miR-4466, and miR-6724 were found in only rDNA-repeating unit. This data might be caused by differences in base alignment between two rRNA sequence data.