Identification of Deleterious Mutations in Myostatin Gene of Rohu Carp (Labeo rohita) Using Modeling and Molecular Dynamic Simulation Approaches

Table 1

List of nsSNPs showing deleterious/nondeleterious scores as predicted by SIFT, PROVEAN, I-Mutant 2, and PANTHER.

Amino acids change; Protein position	subPSEC score		Prediction by; PANTHER-cSNP	PROVEAN score	PROVEAN prediction; (cutoff = −2.5)	DDG value	I-Mutant stability; prediction	SIFT score	Prediction
D76A		0.41009	Deleterious		Deleterious		Decreased	0.02	Deleterious
Q204P		0.73838	Tolerated		Deleterious		Decreased	0.04	Deleterious
C312Y		0.99982	Deleterious		Deleterious		Increased	0.06	Tolerated
D313A		0.3933	Tolerated		Neutral		Increased	0.09	Tolerated