Table 4: Effects of CCC, CFCC, and CAF treatments on the Drosophila melanogaster mean lifespan and healthspan.

Mean lifespan (days)Mean lifespan difference (%)Healthspan (80th percentile) (days)Healthspan difference (%)

CCC (mg/mL)
Control59.68 ± 2.92032.63 ± 1.490
0.78 59.7 ± 2.60.0429.67 ± 2.28−9.08
3.12569.78 ± 2.8216.9337.73 ± 2.5815.63
6.2559.81 ± 2.580.2337.30 ± 2.2614.32
2569.16 ± 3.3915.9034.48 ± 2.175.57
10064.34 ± 3.777.8239.95 ± 0.9622.44

CFCC (mg/mL)
Control66.05 ± 2.17046.30 ± 1.900
0.7865.7 ± 3.23−0.9942.16 ± 3.42−8.93
3.12566.86 ± 2.031.0139.00 ± 5.00−15.77
6.2559.55 ± 3.57−9.8452.05 ± 1.9312.43
2566.06 ± 2.71.042.30 ± 0.67−8.64
10054.71 ± 2.17−18.1738.27 ± 1.09−17.35

CAF (mM)
Control58.84 ± 2.46030.18 ± 1.150
0.004 62.88 ± 1.76.8747 ± 2.6555.73
0.016 64.34 ± 2.759.3536.18 ± 3.5719.87
0.032 68.86 ± 2.3817.0242.35 ± 3.5740.32
0.127 70.91 ± 2.9920.5236.91 ± 3.2222.23
0.5161.14 ± 2.073.9138.15 ± 2.226.41

The difference was calculated by comparing treated flies with the concurrent water control. Positive numbers indicate lifespan increase and negative numbers indicate lifespan decrease. Data are expressed as mean value ± SE. , , and significances obtained with the log-rank (Mantel-Cox) test.