Tanshinone IIA Alleviates the AD Phenotypes in APP and PS1 Transgenic Mice

Figure 2

Tanshinone IIA reversed the impairment of long-term potentiation in AD mice. (a) Impairment of TBS-induced LTP in AD model was improved by Tanshinone IIA administration. (b) LTP level at the 90th min after TBS. (c) Input-output was not affected by Tanshinone IIA application. (d) Paired-pulse facilitation was not affected by Tanshinone IIA application. The data were presented as Mean and SEM. 5–10 slices from five animals were included in each group. compared with WT and compared with AD.

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