Tanshinone IIA Alleviates the AD Phenotypes in APP and PS1 Transgenic Mice

Figure 3

Tanshinone IIA downregulated CTFs and p-Tau expression. (a) APP expression in mRNA level was increased in AD mice. (b) CTFs expression was increased in AD mice, while it was decreased by Tanshinone IIA treatment. Representative blots of CTFs and Actin are inserted above. (c) p-Tau expression was increased in AD mice, while it was decreased by Tanshinone IIA treatment. Representative blots of p-Tau and total Tau are inserted above. The data were presented as Mean and SEM from five animals in each group. , compared with Control and compared with AD.

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