An Approach for Predicting Essential Genes Using Multiple Homology Mapping and Machine Learning Algorithms

Figure 1

Comparison of the number of conserved genes and essential genes between two organisms. (a) We compared the difference between SAS and ESC, two relatively closely related organisms. They shared 3204 orthologous genes and 244 common essential genes. The broken circle represents 353 SAS essential genes, and the dash dotted line circle represents 296 ESC essential genes. For ESC, there are 310 orthologous-essential genes in SAS. (b) We compared the difference between BAT and ESC, two relatively distantly related organisms. They shared 1457 orthologous genes and 123 common essential genes. The broken circle represents 325 BAT essential genes, and the dash dotted line circle represents 296 ESC essential genes. For ESC, there are 198 orthologous-essential genes in BAT. Obviously, the closer species may have more orthologous sequence and more common essential genes with the target species than the distant one.

(a)

(b)