A Nested Case-Control Study of Association between Metabolome and Hypertension Risk

Table 3

Pathways associated with risk of hypertension.

Pathway	Total	Expected	Hit	Metabolites
Phenylalanine, tyrosine, and tryptophan biosynthesis	27	0.26	3	Phenylalanine, tyrosine, shikimic acid
Aminoacyl-tRNA biosynthesis	75	0.72	4	Phenylalanine, glycine, threonine, tyrosine
Nitrogen metabolism	39	0.37	3	Phenylalanine, tyrosine, glycine

Total: the total number of compounds in the pathway. Expected: the expected matched number from the 26 metabolites associated with hypertension. Hit: the actual matched number from the 26 metabolites associated with hypertension. : value calculated from enrichment analysis.