Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2016, Article ID 7658981, 7 pages
http://dx.doi.org/10.1155/2016/7658981
Clinical Study

Vitamin B-6 Supplementation Could Mediate Antioxidant Capacity by Reducing Plasma Homocysteine Concentration in Patients with Hepatocellular Carcinoma after Tumor Resection

1Division of General Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung 40705, Taiwan
2School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
3School of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan
4Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40201, Taiwan

Received 30 December 2015; Accepted 17 February 2016

Academic Editor: Gang Liu

Copyright © 2016 Shao-Bin Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Ferlay, I. Soerjomataram, M. Ervik et al., “GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide,” IARC Cancer Base 11, International Agency for Research on Cancer, Lyon, France, 2013. View at Google Scholar
  2. L. M. Butler, E. Arning, R. Wang et al., “Prediagnostic levels of serum one-carbon metabolites and risk of hepatocellular carcinoma,” Cancer Epidemiology Biomarkers & Prevention, vol. 22, no. 10, pp. 1884–1893, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Galluzzi, E. Vacchelli, J. Michels et al., “Effects of vitamin B6 metabolism on oncogenesis, tumor progression and therapeutic responses,” Oncogene, vol. 32, no. 42, pp. 4995–5004, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Bilski, M. Y. Li, M. Ehrenshaft, M. E. Daub, and C. F. Chignell, “Vitamin B6 (pyridoxine) and its derivatives are efficient singlet oxygen quenchers and potential fungal antioxidants,” Photochemistry and Photobiology, vol. 71, no. 2, pp. 129–134, 2000. View at Google Scholar · View at Scopus
  5. B. K. Ohta and C. S. Foote, “Characterization of endoperoxide and hydroperoxide intermediates in the reaction of pyridoxine with singlet oxygen,” Journal of the American Chemical Society, vol. 124, no. 41, pp. 12064–12065, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Kannan and S. K. Jain, “Effect of vitamin B6 on oxygen radicals, mitochondrial membrane potential, and lipid peroxidation in H2O2-treated U937 monocytes,” Free Radical Biology & Medicine, vol. 36, no. 4, pp. 423–428, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. M. M. Mahfouz and F. A. Kummerow, “Vitamin C or Vitamin B6 supplementation prevent the oxidative stress and decrease of prostacyclin generation in homocysteinemic rats,” The International Journal of Biochemistry & Cell Biology, vol. 36, no. 10, pp. 1919–1932, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Keles, B. Al, K. Gumustekin et al., “Antioxidative status and lipid peroxidation in kidney tissue of rats fed with vitamin B6-deficient diet,” Renal Failure, vol. 32, no. 5, pp. 618–622, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. L. L. Wu and J. T. Wu, “Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker,” Clinica Chimica Acta, vol. 322, no. 1-2, pp. 21–28, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. M. G. Signorello, G. L. Viviani, U. Armani et al., “Homocysteine, reactive oxygen species and nitric oxide in type 2 diabetes mellitus,” Thrombosis Research, vol. 120, no. 4, pp. 607–613, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. M. H. Stipanuk, “Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine,” Annual Review of Nutrition, vol. 24, pp. 539–577, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Wu, Y.-Z. Fang, S. Yang, J. R. Lupton, and N. D. Turner, “Glutathione metabolism and its implications for health,” Journal of Nutrition, vol. 134, no. 3, pp. 489–492, 2004. View at Google Scholar · View at Scopus
  13. L. Yuan and N. Kaplowitz, “Glutathione in liver diseases and hepatotoxicity,” Molecular Aspects of Medicine, vol. 30, no. 1-2, pp. 29–41, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Mena, A. Ortega, and J. M. Estrela, “Oxidative stress in environmental-induced carcinogenesis,” Mutation Research—Genetic Toxicology and Environmental Mutagenesis, vol. 674, no. 1-2, pp. 36–44, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Czeczot, D. Ścibior, M. Skrzycki, and M. Podsiad, “Glutathione and GSH-dependent enzymes in patients with liver cirrhosis and hepatocellular carcinoma,” Acta Biochimica Polonica, vol. 53, no. 1, pp. 237–241, 2006. View at Google Scholar · View at Scopus
  16. C.-C. Lin and M.-C. Yin, “B vitamins deficiency and decreased anti-oxidative state in patients with liver cancer,” European Journal of Nutrition, vol. 46, no. 5, pp. 293–299, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. S.-M. Tsai, S.-K. Lin, K.-T. Lee et al., “Evaluation of redox statuses in patients with hepatitis B virus-associated hepatocellular carcinoma,” Annals of Clinical Biochemistry, vol. 46, no. 5, pp. 394–400, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. R. S. Yahya, O. H. Ghanem, A.-A. A. Foyouh, M. A. Atwa, and S. A. Enany, “Role of interleukin-8 and oxidative stress in patients with hepatocellular carcinoma,” Clinical Laboratory, vol. 59, no. 9-10, pp. 969–976, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. S. N. Zaman, J. M. Tredger, P. J. Johnson, and R. Williams, “Vitamin B6 concentrations in patients with chronic liver disease and hepatocellular carcinoma,” British Medical Journal, vol. 293, no. 6540, p. 175, 1986. View at Google Scholar · View at Scopus
  20. D. Talwar, T. Quasim, D. C. McMillan, J. Kinsella, C. Williamson, and D. S. J. O'Reilly, “Optimisation and validation of a sensitive high-performance liquid chromatography assay for routine measurement of pyridoxal 5-phosphate in human plasma and red cells using pre-column semicarbazide derivatisation,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 792, no. 2, pp. 333–343, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Araki and Y. Sako, “Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection,” Journal of Chromatography B, vol. 422, pp. 43–52, 1987. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Lapenna, G. Ciofani, S. D. Pierdomenico, M. A. Giamberardino, and F. Cuccurullo, “Reaction conditions affecting the relationship between thiobarbituric acid reactivity and lipid peroxides in human plasma,” Free Radical Biology and Medicine, vol. 31, no. 3, pp. 331–335, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. O. Erel, “A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation,” Clinical Biochemistry, vol. 37, no. 4, pp. 277–285, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. N. Ferré, F. Gómez, J. Camps et al., “Plasma homocysteine concentrations in patients with liver cirrhosis,” Clinical Chemistry, vol. 48, no. 1, pp. 183–185, 2002. View at Google Scholar · View at Scopus
  25. A. Bosy-Westphal, M. Ruschmeyer, N. Czech et al., “Determinants of hyperhomocysteinemia in patients with chronic liver disease and after orthotopic liver transplantation,” American Journal of Clinical Nutrition, vol. 77, no. 5, pp. 1269–1277, 2003. View at Google Scholar · View at Scopus
  26. P. Ventura, M. C. Rosa, G. Abbati et al., “Hyperhomocysteinaemia in chronic liver diseases: role of disease stage, vitamin status and methylenetetrahydrofolate reductase genetics,” Liver International, vol. 25, no. 1, pp. 49–56, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. C. C. Hsu, C. H. Cheng, C. Hsu, W. Lee, S. Huang, and Y. Huang, “Role of vitamin B6 status on antioxidant defenses, glutathione, and related enzyme activities in mice with homocysteine-induced oxidative stress,” Food & Nutrition Research, vol. 59, 2015. View at Publisher · View at Google Scholar
  28. M. M. Mahfouz, S. Q. Zhou, and F. A. Kummerow, “Vitamin B6 compounds are capable of reducing the superoxide radical and lipid peroxide levels induced by H2O2 in vascular endothelial cells in culture,” International Journal for Vitamin and Nutrition Research, vol. 79, no. 4, pp. 218–229, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Taysi, “Oxidant/antioxidant status in liver tissue of vitamin B6 deficient rats,” Clinical Nutrition, vol. 24, no. 3, pp. 385–389, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. Z. Rasheed, R. Ahmad, N. Rasheed, and R. Ali, “Reactive oxygen species damaged human serum albumin in patients with hepatocellular carcinoma,” Journal of Experimental & Clinical Cancer Research, vol. 26, no. 3, pp. 395–404, 2007. View at Google Scholar · View at Scopus
  31. H. Tanaka, N. Fujita, R. Sugimoto et al., “Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C,” British Journal of Cancer, vol. 98, no. 3, pp. 580–586, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. J. D. Hayes and L. I. McLellan, “Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress,” Free Radical Research, vol. 31, no. 4, pp. 273–300, 1999. View at Publisher · View at Google Scholar · View at Scopus