Vitamin B-6 Supplementation Could Mediate Antioxidant Capacity by Reducing Plasma Homocysteine Concentration in Patients with Hepatocellular Carcinoma after Tumor Resection
Table 2
Responses of biochemical measurements to placebo or vitamin B-6 supplementation during and after the intervention period1.
Biochemical measurements
Placebo ()
Vitamin B-6 ()
wk 0
wk 4
wk 8
wk 12
wk 0
wk 4
wk 8
wk 12
PLP (nmol/L)
90.6 ± 25.0
96.9 ± 31.0
58.3 ± 7.8
80.3 ± 18.5
91.2 ± 30.8
347.4 ± 77.3
337.9 ± 46.5
354.7 ± 61.3
Liver function
BUN (mg/dL)
15.4 ± 1.3
14.8 ± 1.1
15.9 ± 1.4
15.2 ± 1.0
16.6 ± 1.5
15.4 ± 1.4
15.1 ± 1.3
15.4 ± 1.1
ALT (U/L)
48.6 ± 9.7
50.5 ± 11.0
53.8 ± 14.0
57.5 ± 16.1
48.6 ± 7.1
40.3 ± 4.4
40.5 ± 5.1
49.9 ± 12.4
AST (U/L)
37.1 ± 6.7
36.9 ± 6.8
40.8 ± 9.2
44.1 ± 9.0
32.0 ± 3.5
34.2 ± 4.2
35.4 ± 3.4
38.5 ± 4.6
ALP (U/L)
93.1 ± 13.3
98.3 ± 14.7
105.0 ± 14.6
99.7 ± 13.9
72.5 ± 5.9
73.6 ± 8.3
88.6 ± 10.6
93.6 ± 9.1
Oxidative stress
Homocysteine (mol/L)
12.7 ± 0.9
11.6 ± 1.0
11.6 ± 0.9
11.7 ± 1.0
13.2 ± 0.8
11.5 ± 0.7
10.8 ± 0.9
11.3 ± 0.6
Cysteine (mol/L)
207.6 ± 8.4
195.8 ± 7.7
206.6 ± 7.2
219.1 ± 8.9
210.4 ± 9.7
186.8 ± 4.9
188.9 ± 7.2
220.5 ± 9.9
MDA (mol/L)
0.9 ± 0.2
1.0 ± 0.2
0.8 ± 0.1
0.8 ± 0.1
1.0 ± 0.1
1.0 ± 0.1
0.8 ± 0.1
0.8 ± 0.1
Antioxidant capacities
TEAC (mol/L)
4647.3 ± 129.2
4593.0 ± 109.2
4788.4 ± 139.1
4775.0 ± 132.0
4599.4 ± 79.7
4584.9 ± 124.5
4619.2 ± 115.8
5012.7 ± 127.3
SOD (U/mL)
11.3 ± 0.9
11.9 ± 1.2
11.0 ± 1.3
11.5 ± 0.7
12.3 ± 1.0
13.4 ± 1.2
13.6 ± 1.8
13.4 ± 1.8
GSH (g/mL)
17.9 ± 1.9
11.8 ± 1.1
11.9 ± 1.2
14.2 ± 1.4
17.9 ± 2.4
12.8 ± 2.1
10.1 ± 1.3
11.7 ± 0.9
GSSG (g/mL)
408.7 ± 19.5
393.2 ± 12.8
407.3 ± 10.7
442.1 ± 15.6
391.5 ± 18.1
385.4 ± 12.0
402.5 ± 7.0
411.2 ± 18.4
GSH/GSSG ratio (×10−2)
4.4 ± 1.9
3.0 ± 0.3
3.0 ± 0.4
3.3 ± 0.4
4.7 ± 0.6
3.4 ± 0.6
2.5 ± 0.3
2.7 ± 0.2
GPx (nmol/min/mL)
145.7 ± 20.2
117.5 ± 17.0
153.5 ± 29.0
169.6 ± 16.8
157.0 ± 19.1
120.6 ± 15.3
136.9 ± 16.5
164.8 ± 20.7
GR (nmol/min/mL)
59.9 ± 2.7
57.1 ± 3.6
59.5 ± 4.5
62.9 ± 4.9
70.7 ± 3.9
55.9 ± 3.1
54.4 ± 2.6
54.7 ± 2.7
GST (nmol/min/mL)
40.8 ± 3.5
35.3 ± 3.3
39.5 ± 5.5
37.5 ± 5.7
38.4 ± 4.8
32.4 ± 4.1
45.7 ± 3.7
41.9 ± 4.1
Values are means ± standard error of mean (SE). PLP: pyridoxal 5′-phosphate; BUN: blood urea nitrogen; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; MDA: malondialdehyde; TEAC: trolox equivalent antioxidant capacity; SOD: superoxide dismutase; GSH: glutathione; GSSG: oxidized glutathione; GPx: glutathione peroxidase; GR: glutathione reductase; GST: glutathione S-transferase. Values with different superscript letters are significantly different within the group (). Values are significantly different from the placebo group at week 0 (). Values are significantly different from the placebo group at week 4 (). †Values are significantly different from the placebo group at week 8 (). ††Values are significantly different from the placebo group at week 12 ().
