Altered Expression of EPO Might Underlie Hepatic Hemangiomas in LRRK2 Knockout Mice

Figure 1

Hepatic hemangiomas in LRRK2 mutant mice. (a) Gross morphology of a large hemangioma (left) and a small hemangioma (right). (b) Incidence of hepatic hemangiomas detected in LRRK2^−/− mice at different ages. (c) Histological staining of WT control (left, 23 months of age) and LRRK2^−/− (middle and right, 23 and 25 months of age, resp.) mutant liver sections. Large vascular spaces filled with blood cell were observed in LRRK2^−/− mice. Scale bars: 200 μm. (d, e) Western blotting indicates that no obvious LRRK2 expression is detected in the livers at ages of 2 months ((d), upper panel) and 23 months ((e), upper panel). Quantitative RT-PCR showing relative expression levels of LRRK2 mRNAs in the kidneys and livers of WT and KO mice () at the ages of 2 months ((d), lower panel) and 23 months ((e), lower panel). All data are expressed as mean ± SEM.

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