Altered Expression of EPO Might Underlie Hepatic Hemangiomas in LRRK2 Knockout Mice

Figure 2

Increased erythropoietin (EPO) expression in the livers of HA-positive LRRK2^−/− mice. Immunohistochemical analysis of HIF-2α expression in the livers of HA-positive LRRK2^−/− mice at the age of 22-23 months. Nuclear HIF-2α staining was detected in clusters of cells near the vascularized vessels. Scale bars: 50 μm. qRT-PCR analysis of EPO (b) and VEGF (c) mRNA levels in the livers of 22-23-month-old mice. (d) qRT-PCR analysis of VEGF mRNA levels in the livers of mice at ages of 2, 12, and 18-19 months. ns, not significant.

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