Lamotrigine Reduces Inflammatory Response and Ameliorates Executive Function Deterioration in an Alzheimer’s-Like Mouse Model

Figure 2

Lamotrigine decreased IL-6 and IL-1β production and inhibited GAFP expression in brain cortex of APP/PS1 mice. (a) IL-6 was measured with ELISA kit in the brain tissue of cortical area of WT and APP/PS1 mice with or without lamotrigine treatment (). . (b) IL-1β was measured with ELISA kit in the brain tissue of cortical area of WT and APP/PS1 mice with or without lamotrigine treatment (). . (c) GFAP expression in APP/PS1 mouse brain cortex was measured with western blot analysis in the brain tissue of cortical area of APP/PS1 mice with or without lamotrigine treatment (). . All data are expressed as means ± SEM.

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