Lamotrigine Reduces Inflammatory Response and Ameliorates Executive Function Deterioration in an Alzheimer’s-Like Mouse Model

Figure 3

Lamotrigine inhibits IL-1β production of cultured astrocytes from APP/PS1 mice. (a) Representative photograph of 4-week-old cultures astrocytes labeled with the specific marker protein of GFAP and Hochest 33258 for nucleus staining. (b) IL-1β was measured with ELISA kit in the cultured astrocytes treated with lamotrigine for 24 hours at different doses (). = 14–17. (c) IL-1β expression level was measured with western blot analysis in cultured astrocyte treated with 500 μM lamotrigine for 24 hours (). . All data are expressed as means ± SEM.

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