Lamotrigine Reduces Inflammatory Response and Ameliorates Executive Function Deterioration in an Alzheimer’s-Like Mouse Model

Figure 4

Lamotrigine attenuates executive function deficits of APP/PS1 mice in a puzzle box test. (a) Latencies of mice in each group to complete the task on day 1 (T1–T3). (b) Latencies of mice in each group to complete the task on day 1 (T4–T6). (c) Latencies of mice in each group to complete the task on day 1 (T7–T9). (d) Latencies of mice in each group to solve a new problem during the 3-day test. (e) Latencies of mice in each group to solve a repeat new problem after 3-minute interval during the 3-day test (short-term memory). (f) Latencies of mice in each group to solve a repeat new problem after 24-hour interval during the 3-day test (long-term memory). All data are expressed as means ± SEM. versus WT; versus APP/PS1, .

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