Advanced Glycation End Products Induce Obesity and Hepatosteatosis in CD-1 Wild-Type Mice

Figure 6

Leptin and cytokine levels (IL-6 and TNF-α) after 4 and 6 weeks on the diets. Consistent with the weight gain and epididymal fat pad weights, leptin levels were significantly higher after 4 and 6 weeks in the HAGE-HF group compared to the other groups. Also consistent with the liver histology and presence of inflammation after 6 weeks on the diet, IL-6 and TNF-α levels were significantly higher in the HAGE-HF group after 6 weeks on the diet.