Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma

Table 2

Measured plasma MCP-1 levels based on clinical parameters in patients with MM.

Clinical feature	MCP-1 (pg/mL)
	Median		Range
Renal dysfunction
No	91.5		8.3–277.4
Yes	120.3		84.7–299.5
value		0.02
Anemia
No	78.9		8.3–170.2
Yes	109.5		32.1–299.5
value		0.04
Bone disease
No	86.4		8.3–138.9
Yes	110.3		32.1–299.5
value		0.01

values are based on the Mann-Whitney test.
Renal dysfunction = serum creatinine level above the upper limit of normal; anemia = hemoglobin value 20 g/L below the lower limit of normal; bone disease = presence of any lytic lesion or severe osteopenia with compressive fractures on standard bone radiographs.