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BioMed Research International
Volume 2016, Article ID 7870925, 7 pages
Research Article

Serum Heme Oxygenase-1 and BMP-7 Are Potential Biomarkers for Bone Metabolism in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis

1Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China
2Department of Health Statistics, West China School of Public Health, Sichuan University, Chengdu 610041, China
3Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
4Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
5Institute of Integrative Medicine, China Medical University, Taichung 40201, Taiwan
6Department of Internal Medicine 3, University of Erlangen-Nuremberg, 91054 Erlangen, Germany

Received 12 April 2016; Revised 4 May 2016; Accepted 5 May 2016

Academic Editor: Hai-Feng Pan

Copyright © 2016 Tong-ling Yuan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Serum levels of biomarkers in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and in the controls. Data were given as median (IQR). Data compared by Kruskal-Wallis H test, followed by Dunn’s multiple comparisons test, except sex by chi-square test. A p value < 0.0167 is considered significant after Bonferroni correction for multiple testing. p values were comparisons among RA, AS and Control samples. &Significant difference compared between RA and AS (p < 0.05, data not shown). n.s.: the variables were included in analysis, but not significantly different between the three groups by Kruskal-Wallis H test. IQR: interquartile range; NMID: N-terminal mid-fragment of osteocalcin; BALP: bone alkaline phosphatase; CTX: C-terminal telopeptide of type I collagen; TRAP-5b: Tartrate-resistant acid phosphatase-5b.

  1. Supplementary Material