Serum Heme Oxygenase-1 and BMP-7 Are Potential Biomarkers for Bone Metabolism in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis

Table 3

Correlation between serum levels of HO-1, BMP-7, and Runx2 and measurements of disease activity and severity in patients with RA and AS. Correlations were performed using Spearman’s correlation coefficient ().

	RA ()			AS ()
	ESR, mm/h	CRP, mg/L	DAS28-ESR score	ESR, mm/h	CRP, mg/L	BASDAI score	BASFI score	BASMI score
ESR, mm/h								0.284
CRP, mg/L
HO-1, ng/mL	−0.068	−0.049	−0.118	−0.205	−0.068	−0.163	−0.197	−0.156
BMP-7, ng/mL	0.030	−0.096	0.001	−0.026	−0.203	0.023	−0.059	−0.119
Runx2, ng/mL	0.010	0.186	−0.048	0.051	0.209	0.103	0.286

⁢; . RA: rheumatoid arthritis; AS: ankylosing spondylitis; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; HO-1: heme oxygenase-1; BMP-7: bone morphogenetic protein-7; Runx2: Runt related-transcription factor 2; DAS28-ESR: Disease Activity Scores 28 using ESR; BASDAI: Bath Ankylosing Spondylitis (BAS) Disease Activity Index; BASFI: BAS Functional Index; BASMI: BAS Metrology Index.