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BioMed Research International
Volume 2016, Article ID 7891202, 13 pages
Research Article

17β-Estradiol Promotes Schwann Cell Proliferation and Differentiation, Accelerating Early Remyelination in a Mouse Peripheral Nerve Injury Model

1Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China
2Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China
3Department of Anatomy, Chengdu University, Chengdu 610106, China
4The Joint Laboratory for Reproductive Medicine of Sichuan University-The Chinese University of Hong Kong, West China Second University Hospital, Sichuan University, Chengdu 610041, China

Received 27 July 2016; Accepted 4 October 2016

Academic Editor: Markus Kipp

Copyright © 2016 Yan Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

In the supplementary materials, we provided to readers some additional experimental data to increase the credibility of this research. In Figure S1, we showed the process of the “nerve bridge” formation, and the morphological difference between “nerve bridge” site and the distal stump site of the injured nerve. In Figure S2, we provided to the readers more proofs that E2 promotes Schwann cells proliferation in vitro and in vivo. Finally in Figure S3, we demonstrated the regulating role of E2 on the ERK signaling in Schwann cells.

  1. Supplementary Material