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BioMed Research International
Volume 2016 (2016), Article ID 7936902, 9 pages
http://dx.doi.org/10.1155/2016/7936902
Research Article

Acoustic Cavitation Enhances Focused Ultrasound Ablation with Phase-Shift Inorganic Perfluorohexane Nanoemulsions: An In Vitro Study Using a Clinical Device

1State Key Laboratory of Ultrasound Engineering in Medicine, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China
2HIFU Unit, The Churchill Hospital, Oxford University Hospitals, Headington, Oxford OX3 7LE, UK

Received 18 February 2016; Accepted 15 May 2016

Academic Editor: Enzo Terreno

Copyright © 2016 Lu-Yan Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. E. Kennedy, “High-intensity focused ultrasound in the treatment of solid tumours,” Nature Reviews Cancer, vol. 5, no. 4, pp. 321–327, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. J. F. Ward, “High-intensity focused ultrasound for therapeutic tissue ablation in surgical oncology,” Surgical Oncology Clinics of North America, vol. 20, no. 2, pp. 389–407, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. C. M. C. Tempany, N. J. McDannold, K. Hynynen, and F. A. Jolesz, “Focused ultrasound surgery in oncology: overview and principles,” Radiology, vol. 259, no. 1, pp. 39–56, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Elbes, Q. Denost, C. Laurent, H. Trillaud, A. Rullier, and B. Quesson, “Pre-clinical study of in vivo magnetic resonance-guided bubble-enhanced heating in pig liver,” Ultrasound in Medicine and Biology, vol. 39, no. 8, pp. 1388–1397, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. D. J. Chung, S. H. Cho, J. M. Lee, and S.-T. Hahn, “Effect of microbubble contrast agent during high intensity focused ultrasound ablation on rabbit liver in vivo,” European Journal of Radiology, vol. 81, no. 4, pp. e519–e523, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Okita, K. Sugiyama, S. Takagi, and Y. Matsumto, “Microbubble behavior in an ultrasound field for high intensity focused ultrasound therapy enhancement,” Journal of the Acoustical Society of America, vol. 134, no. 2, pp. 1576–1585, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Mullin, R. Gessner, J. Kwan, M. Kaya, M. A. Borden, and P. A. Dayton, “Effect of anesthesia carrier gas on in vivo circulation times of ultrasound microbubble contrast agents in rats,” Contrast Media and Molecular Imaging, vol. 6, no. 3, pp. 126–131, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Ferrara, R. Pollard, and M. Borden, “Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery,” Annual Review of Biomedical Engineering, vol. 9, pp. 415–447, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. N. J. McDannold, N. I. Vykhodtseva, and K. Hynynen, “Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits,” Radiology, vol. 241, no. 1, pp. 95–106, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Zhang, M. L. Fabiilli, K. J. Haworth et al., “Acoustic droplet vaporization for enhancement of thermal ablation by high intensity focused ultrasound,” Academic Radiology, vol. 18, no. 9, pp. 1123–1132, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. J. A. Kopechek, E.-J. Park, Y.-Z. Zhang, N. I. Vykhodtseva, N. J. McDannold, and T. M. Porter, “Cavitation-enhanced MR-guided focused ultrasound ablation of rabbit tumors in vivo using phase shift nanoemulsions,” Physics in Medicine and Biology, vol. 59, no. 13, pp. 3465–3481, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. X. Wang, H. Chen, Y. Chen et al., “Perfluorohexane-encapsulated mesoporous silica nanocapsules as enhancement agents for highly efficient high intensity focused ultrasound (HIFU),” Advanced Materials, vol. 24, no. 6, pp. 785–791, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. L. C. Phillips, C. Puett, P. S. Sheeran, G. Wilson Miller, T. O. Matsunaga, and P. A. Dayton, “Phase-shift perfluorocarbon agents enhance high intensity focused ultrasound thermal delivery with reduced near-field heating,” The Journal of the Acoustical Society of America, vol. 134, no. 2, pp. 1473–1482, 2013. View at Publisher · View at Google Scholar
  14. Y. Zhou, Z. Wang, Y. Chen et al., “Microbubbles from gas-generating perfluorohexane nanoemulsions for targeted temperature-sensitive ultrasonography and synergistic HIFU ablation of tumors,” Advanced Materials, vol. 25, no. 30, pp. 4123–4130, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Rapoport, K.-H. Nam, R. Gupta et al., “Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions,” Journal of Controlled Release, vol. 153, no. 1, pp. 4–15, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Takegami, Y. Kaneko, T. Watanabe, T. Maruyama, Y. Matsumoto, and H. Nagawa, “Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound,” Ultrasound in Medicine and Biology, vol. 30, no. 10, pp. 1419–1422, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. W.-S. Chen, A. A. Brayman, T. J. Matula, L. A. Crum, and M. W. Miller, “The pulse length-dependence of inertial cavitation dose and hemolysis,” Ultrasound in Medicine and Biology, vol. 29, no. 5, pp. 739–748, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. C.-Y. Lin and W. G. Pitt, “Acoustic droplet vaporization in biology and medicine,” BioMed Research International, vol. 2013, Article ID 404361, 13 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Chen, H. Chen, and J. Shi, “Nanobiotechnology promotes noninvasive high-intensity focused ultrasound cancer surgery,” Advanced Healthcare Materials, vol. 4, no. 1, pp. 158–165, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Zhang, M. L. Fabiilli, K. J. Haworth et al., “Initial investigation of acoustic droplet vaporization for occlusion in canine kidney,” Ultrasound in Medicine and Biology, vol. 36, no. 10, pp. 1691–1703, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Chapman and G. ter Haar, “Thermal ablation of uterine fibroids using MR-guided focused ultrasound-a truly non-invasive treatment modality,” European Radiology, vol. 17, no. 10, pp. 2505–2511, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Brotchie, F. Grieser, and M. Ashokkumar, “Effect of power and frequency on bubble-size distributions in acoustic cavitation,” Physical Review Letters, vol. 102, no. 8, Article ID 084302, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Xu, T. A. Bigelow, and H. Lee, “Effect of pulse repetition frequency and scan step size on the dimensions of the lesions formed in agar by HIFU histotripsy,” Ultrasonics, vol. 53, no. 4, pp. 889–896, 2013. View at Publisher · View at Google Scholar · View at Scopus