NRAMP1 Polymorphisms like Susceptibility Marker in Mexican Focus of Cutaneous Leishmaniasis
Table 3
Genotype frequency of the NRAMP1 polymorphisms.
Genotypes
CL (%)
Controls (%)
value
OR (95% CI)
Promoter region −524
Promoter region −524 G/G
115 (100)
69 (100)
Not statistically significant
Promoter region −524 G/C
0
0
Promoter region −524 C/C
0
0
Exon 3 274
Exon 3 274 C/C
48 (41.73)
35 (50.72)
Not statistically significant
Exon 3 274 C/T
51 (44.34)
27 (39.13)
Exon 3 274 T/T
16 (13.91)
7 (10.14)
Exon 8 823
Exon 8 823 C/C
92 (80)
68 (98.55)
13.26
17.00 (2.24–128.99)
Exon 8 823 C/T
18 (15.65)
1 (1.44)
Exon 8 823 T/T
5 (4.34)
0
Exon 15 D543N
Exon 15 D543N G/G
75 (65.21)
52 (75.36)
Not statistically significant
Exon 15 D543N G/A
40 (34.78)
16 (23.18)
Exon 15 D543N A/A
0
1 (1.44)
3′UTR
3′UTR TGTG/TGTG
65 (56.52)
54 (78.26)
9.6
2.76 (1.40–5.46)
3′UTR TGTG/del
3 (2.6)
0
3′UTR del/del
47 (40.86)
15 (21.73)
value = Chi-square value with in the presence of the mutation and CL. OR = odds ratio (95% confidence interval) presence of mutation is a risk for CL. UTR = untranslated region. del = deletion.
