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BioMed Research International
Volume 2016, Article ID 8091353, 9 pages
Research Article

The HPV16 E7 Oncoprotein Disrupts Dendritic Cell Function and Induces the Systemic Expansion of CD11b+Gr1+ Cells in a Transgenic Mouse Model

1Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), 07360 Mexico City, CDMX, Mexico
2Unit of Health Sciences, Faculty of Odontology, Universidad Autónoma de Baja California, 21100 Mexicali, BC, Mexico
3Research Unit, Hospital Juárez de México, 07760 Mexico City, CDMX, Mexico
4McArdle Laboratory for Cancer Research, University of Wisconsin, School of Medicine and Public Health, Madison, WI 53726, USA

Received 2 February 2016; Revised 5 May 2016; Accepted 13 June 2016

Academic Editor: Kevin M. Coombs

Copyright © 2016 Gabriela Damian-Morales et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The morphology of MHC-II+ and CD205+ cells was also evaluated by IHC in hyperplastic skin from K14E7 mice. Similar to immunofluorescence results the LCs displayed a round shape and less number of dendrites.

  1. Supplementary Material