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BioMed Research International
Volume 2016 (2016), Article ID 8103019, 6 pages
http://dx.doi.org/10.1155/2016/8103019
Research Article

Predictive Significance of Serum Level of Vascular Endothelial Growth Factor in Gastric Cancer Patients

Department of Clinical Laboratory, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute, Beijing 100142, China

Received 2 June 2016; Revised 12 July 2016; Accepted 12 July 2016

Academic Editor: Mario Scartozzi

Copyright © 2016 Lu Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The study aims to evaluate serum VEGF expression in gastric cancer patients and investigate its relationship with clinicopathological parameters. We also examined the serum VEGF levels in GC patients having received surgery or chemotherapy treatment to assess its predictive and prognostic value as a biomarker. We enrolled 154 GC patients having not received neoadjuvant treatment and 100 healthy controls. In the treatment groups, 13 surgery patients and 15 chemotherapy patients were investigated. 42 chemotherapy patients with different chemotherapy efficacy were recruited as well. The serum VEGF was examined by ELISA. Serum VEGF level was remarkably upregulated in GC group compared with healthy group (). The serum VEGF level of GC group was significantly correlated with tumor cells differentiation degree, clinical stages, tumor infiltration depth, lymph node metastasis, and tumor size. The serum VEGF level of the 1 to 3 days after operation group was much lower than that of the preoperative group () and the 7 days after operation group (). By contrast, serum VEGF level was decreased significantly after chemotherapy (). Importantly, serum VEGF level in PD+SD group was significantly higher compared to the PR+CR group (). Therefore, serum VEGF was a valuable biomarker in clinically monitoring the condition of GC patients.