SIRT3 Expression Decreases with Reactive Oxygen Species Generation in Rat Cortical Neurons during Early Brain Injury Induced by Experimental Subarachnoid Hemorrhage

Figure 2

Real-time PCR analysis of SIRT3 and SOD2 mRNA levels at multiple time points after experimental SAH. (a) The mRNA level of SIRT3 decreased following SAH and was at its minimum at 24 h after experimental SAH. (b) The mRNA level of SOD2 increased slowly as early as 12 hours after experimental SAH, rose up sharply at the following 12 hours, and then was maintained at a higher level. Data were shown as mean ± SEM. Number of animals: for each group and versus sham group, respectively; ns = not significant between two groups ().

(a)

(b)