Clinical Study
CT-Guided 125I Seed Interstitial Brachytherapy as a Salvage Treatment for Recurrent Spinal Metastases after External Beam Radiotherapy
Table 2
Treatment details for the four patients receiving a second brachytherapy.
| | Number | GTV volume (cc) | Seed activity (mCi) | Number of seeds/ (Gy) | GTV: (%) | of spinal cord (Gy) | Therapy after seed implant | RR | LR (m) | Pain-free survival (m) | Cause of death | OS (m) |
| | 1 | 72.5
60.3 | 0.7
0.8 | 74/93.2
73/121.5 | 90.2/89.3
93.2/90.1 | 35.7
25.6 | No | PD
SD | 6
18 | 6 | MM | 24 | | 2 | 61.3
61.3 | 0.6
0.8 | 57/92.2
51/93.5 | 83.5/81.9
85.8/82.1 | 35.6
6.0 | No | SD
SD | 3
9 | 3 | MM | 12 | | 3 | 59.3
48.5 | 0.8
0.7 | 75/158.3
46/91.8 | 96.3/94.9
85.6/81.6 | 38.4
30.6 | No | PR
SD | 3
3 | 3 | MM | 14 | | 4 | 121.4
17.9 | 0.7
0.8 | 88/92.2
23/139.3 | 85.5/82.2
97.8/95.6 | 61.1
25.0 | No | SD
SD | 3
6 | 3 | MM | 6 |
|
|
RR = response rate; PR = partial response; SD = stable disease; PD = progressive disease; LR = local recurrence; m = months; MM = multiple metastasis; SS = survival; OS = overall survival after seed implantation.
|
