Correlation-Based Network Generation, Visualization, and Analysis as a Powerful Tool in Biological Studies: A Case Study in Cancer Cell Metabolism

Figure 2

Correlation-based networks of metabolite data sets. (a) Original network under control conditions, (b) original network under hypoxic conditions, (c) network of unique relationships under control conditions compared to hypoxic conditions, and (d) network of unique relationships under hypoxic conditions compared to control conditions. Metabolic profiling of breast cancer cells under control and hypoxia (30 samples each) was used for pairwise correlation analysis between metabolites and network-view production. The data used to generate the network is from Kotze et al., 2013 [20]. Each vertex represents a metabolite; each edge represents a significant correlation between pairs of metabolites across samples. Vertex colors reflect biochemical classes: amino acids and N-compounds (blue), sugars and sugar alcohols (orange), and carboxylic acids (green). Vertex size reflects degree.

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