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BioMed Research International
Volume 2016 (2016), Article ID 8363179, 1 page

Neurodegeneration: Etiologies and New Therapies 2016

1Department of Neurology, Singapore General Hospital, National Neuroscience Institute and Duke NUS Graduate Medical School, Singapore 169857
2Department of Pediatric Surgery, University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA
3Department of Neurology, Division of Neuromuscular Disorders and Department of PM&R and Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
4Toxicogenomics and Predictive Toxicology Division, CSIR-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh 226 001, India
5Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA

Received 3 October 2016; Accepted 5 October 2016

Copyright © 2016 Eng King Tan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

In this special issue, we have 9 articles that highlight diverse biochemical, immunological, molecular, and neuroimaging techniques used to decipher the pathophysiological mechanisms underpinning neurodegeneration in various cellular and animal models. The common diseases are covered, including a review on the therapeutic options in Alzheimer’s disease and a discussion on the factors influencing homocysteine levels in Parkinson’s disease. Of particular interest in this issue is an article on the entity of “chemo brain,” a condition that overlaps between oncology and neurology. “Chemo brain” is a common term used to describe thinking and memory problems that can occur after cancer treatment. Here the authors demonstrate PET evidence of the effect of donepezil on cognitive performance in an animal model. We hope this special issue will generate further interest and debate on the pathoetiology of neurodegenerative diseases and provide a platform to generate impetus to further identify and validate new therapeutic options.

Eng King Tan
Amit K. Srivastava
W. David Arnold
Mahendra P. Singh
Yiying Zhang