Deposition of BACE-1 Protein in the Brains of APP/PS1 Double Transgenic Mice

Figure 1

Plaque deposition and memory/cognition deficits in APP/PS1 mice at 6 months of age. Congo Red staining showed the amyloid plaques in the brain of APP/PS1 mice (a). APP/PS1 mice showed reduced spontaneous alternation in Y maze test (b). APP/PS1 mice showed increased trend of total arm entry in Y maze test (c). APP/PS1 mice showed increased escape latency in hidden platform test of water maze compared to WT mice (d). APP/PS1 mice showed less time spent in the target quadrant in probe test of water maze (e). Scale bar represents 500 μm. Data are expressed as means ± SEM. -8, each group. versus WT.

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