N-¹¹C-Methyl-Dopamine PET Imaging of Sympathetic Nerve Injury in a Swine Model of Acute Myocardial Ischemia: A Comparison with ¹³N-Ammonia PET

Table 2

Comparison of defect scores, ischemic-to-normal ratios, and volume of ischemic myocardium for ¹¹C-N-CH₃-dopamine and ¹³N-ammonia PET imaging at each time point after myocardial ischemia-reperfusion.

Time	Defect score			Ischemic-to-normal ratio			Volume of ischemic myocardium (cm^3)
	^11C-N-CH3-dopamine	^13N-Ammonia		^11C-N-CH3-dopamine	^13N-Ammonia		^11C-N-CH3-dopamine	^13N-Ammonia
1 day	10.2 ± 2.5	9.9 ± 0.9	NS	0.61 ± 0.12	0.61 ± 0.08	NS	3.79 ± 0.06	3.66 ± 0.08	NS
1 month	13.3 ± 3.3	7.7 ± 1.0	<0.001	0.51 ± 0.22	0.60 ± 0.10	<0.05	4.21 ± 0.34	2.54 ± 0.11	<0.001
3 months	18.6 ± 4.4	4.9 ± 1.0	<0.001	0.42 ± 0.13	0.60 ± 0.09	<0.05	10.67 ± 0.71	2.47 ± 0.12	<0.001
6 months	10.7 ± 4.2	4.1 ± 0.9	<0.001	0.60 ± 0.17	0.60 ± 0.09	NS	5.96 ± 0.50	2.43 ± 0.11	<0.001