Antiobesity and Antidiabetes Effects of a Cudrania tricuspidata Hydrophilic Extract Presenting PTP1B Inhibitory Potential

Figure 2

Time line of the experimental procedures using the diet-induced obesity (DIO) mouse model, and effects of CTe on the body weight of DIO mice. (a) C57BL/6 mice were treated daily with vehicle or 60% high fat diet (HFD) by oral gavage for 12 weeks. Week 0 is the starting point beginning on the 1st week with normal chow. The mice were treated with a placebo for 3 weeks prior to CTe treatment. The vehicle group received the placebo treatment for 6 weeks without oral administration of CTe (upper panel). The HFD-fed mice were orally administered CTe or a positive control (PC; sibutramine or sitagliptin) for 1 month (lower panel). (b) Body weights of DIO mice treated with vehicle or CTe (20 or 100 mg/kg) for 3 weeks. Sibutramine was used as a positive control. Data are presented as the mean ± SD for each group (). and versus vehicle administered DIO mice.

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