Comparison and Prognostic Analysis of Adjuvant Radiotherapy versus Salvage Radiotherapy for Treatment of Radically Resected Locally Advanced Esophageal Squamous Cell Carcinoma
Table 2
Univariate and subgroup analysis of overall survival (OS) and disease-free survival (DFS) in the two treatment groups.
Median OS (months)
Median DFS (months)
Adjuvant radiotherapy group
Salvage radiotherapy group
P value
Adjuvant radiotherapy group
Salvage radiotherapy group
P value
Gender
Male
33.4
26.9
25.9
12.4
Female
27.6
25.4
0.20
18.6
7.7
value
0.85
0.18
0.87
0.04
Age
>65 years
15.9
19.7
0.84
13.9
7.9
0.06
≤65 years
39.9
32.1
28.8
13.4
value
0.10
0.10
Performance status
<2, (%)
84.9
38.0
37.2
12.4
≥2, (%)
17.6
23.3
0.56
12.0
10.7
0.14
value
0.46
Surgical-pathological stage
II
71.4
25.4
37.2
10.7
III
23.3
26.4
0.20
13.9
9.2
value
0.23
0.19
pT stage
2
NA
25.3
NA
12.4
3
26.3
26.5
0.07
19.2
9.2
4
32.5
31.0
0.40
22.5
21.9
0.44
value
0.26
0.81
0.10
0.37
pN status
−
36.8
31.6
0.06
26.3
14.6
+
30.6
23.5
0.06
18.7
8.9
value
0.40
0.06
0.33
Histologic grade
1
95.7
11.5
0.05
37.2
3.2
2
27.6
26.5
0.19
20.1
11.2
3
NA
23.37
0.05
NA
10.7
value
0.27
0.93
0.34
0.06
Tumor location
Upper
62.0
30.0
0.14
NA
5.4
Middle
30.1
25.3
0.07
20.1
10.7
Lower
35.2
26.4
0.09
22.57
11.2
value
0.20
0.40
0.32
Adjuvant chemotherapy
Yes
33.43
31.0
30.4
14.57
No
26.3
23.3
0.12
22.5
6.9
value
0.32
0.43
0.90
< 0.05. NA: the median OS or DFS had not been reached.
