Renal Ischemia/Reperfusion Injury in Diabetic Rats: The Role of Local Ischemic Preconditioning

Table 2

Histopathologic scores in groups.

Groups	Proximal tubulus	Mononuclear cell infiltration	Capillary vasodilation	Total cell injury score
Group I (nondiabetic sham); ()	0.14 ± 0.38; 0.0; 0-1	0.29 ± 0.49; 0.0; 0-1	0.29 ± 0.49; 0.0; 0-1	0.71 ± 1.11; 0.0; 0–3
Group II (diabetic sham); ()	1.33 ± 0.52; 1.0; 1-2	1.33 ± 0.52; 1.0; 1-2	1.17 ± 0.41; 1.0; 1-2	3.83 ± 0.98; 3.5; 3–5
Group III (diabetic IR); ()	1.83 ± 0.41; 2.0; 1-2	1.66 ± 0.52; 2.0; 1-2	1.5 ± 0.55; 1.5; 1-2	5.0 ± 1.09; 5.0; 4–6
Group IV (diabetic IR + LIPC); ()	2.33 ± 0.52; 2.0; 2-3	2.17 ± 0.75; 2.0; 1–3	2.17 ± 0.41; 2.0; 2-3	6.67 ± 0.82; 6.5; 6–8
values
	0.003	0.008	0.010	0.004
	0.001	0.004	0.006	0.002
	0.001	0.003	0.001	0.002
	0.093	0.269	0.241	0.082
	0.014	0.057	0.006	0.003
	0.092	0.206	0.043	0.020

Group I: nondiabetic sham, Group II: diabetic sham, Group III (diabetic IR): renal ischemia/reperfusion injury in diabetic rats group, and Group IV (diabetic IR + LIPC): renal ischemia/reperfusion injury in diabetic rats group and local ischemia preconditioning; Mann-Whitney test was conducted to compare two independent groups. Values are mean ± 1 SD, median (minimum-maximum).
: comparison of nondiabetic sham and diabetic sham.
: comparison of nondiabetic sham and diabetic IR.
: comparison of nondiabetic sham and diabetic IR + LIPC.
: comparison of diabetic sham and diabetic IR.
: comparison of diabetic sham and diabetic IR + LIPC.
: comparison of diabetic IR and diabetic IR + LIPC.