A Naphthalenic Derivative ND-1 Inhibits Thrombus Formation by Interfering the Binding of Fibrinogen to Integrin αIIbβ3

Figure 1

Chemical structure of ND-1 and effect on platelet aggregation. (a) Chemical structure of ND-1. ((b) to (e)) Effect of ND-1 on platelet aggregation. Platelet-rich plasma was preincubated with indicated concentrations of ND-1 or vehicle for 5 min at 37°C. Aggregation was initiated by the addition of 20 μM ADP (b), 1 μg/mL collagen (c), 0.25 U/mL thrombin (d), or 2 μM U46619 (e). Data are presented as mean ± SD (). , compared with vehicle.

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