[¹⁸F]FDG Uptake in the Aortic Wall Smooth Muscle of Atherosclerotic Plaques in the Simian Atherosclerosis Model

Figure 5

Histological analysis of thoracic aorta of rabbit model of atherosclerosis. The arterial slices in the normal and WHHL rabbits at age of 6 months ((a–d), normal; (e–h), WHHL). H&E staining (a and e) and ex vivo macro-autoradiograms with [¹⁸F]FDG (b and f) and fusion images (c and g). (d and h) are the corresponding sections from dashed line of (c and g), respectively. Arterial [¹⁸F]FDG uptake values which were quantified with serial 2 slices from each animal were compared between the normal and WHHL rabbits (i). versus control. The data represent mean and s.e.m. ( slices). Immunohistochemical staining of macrophage by RAM11, anti-rabbit macrophage, in the arterial vessel ((j), normal; (k), WHHL). Red arrows indicate RAM-positive cells in the aorta of WHHL rabbit. The slices at 20 μm thickness. (a–c), (e–g), bar = 1 mm; (d), (j), and (k), bar = 300 μm.

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