Gene dbSNP [24 ] rel. 146 Circadian complications and comorbidities whose candidate SNP markers were predicted in [this work] (clinical data, laboratory animals, or cellular model) [References] found (see Figure 2 ) ID SNP wt →mut 5′ flank wt mut 3′ flank wt mut Δ CLOCK rs192518038 -57g →t aggacctaag g t ctagcgctct 63 29 ↑ 14 10−6 (Hypothetically) higher risk of heart attacks that are characterized by circadian preference for the early morning in the elderly with diabetes (CLOCK-mutant mice) [This work] [92 ] rs537333415 -63c →t gcctccagga c t ctaaggctag 63 45 ↑ 7 10−6 ARNTL rs534789405 -28g →a cggattggct g a ggggcggccg 184 89 ↑ 12 10−6 (Hypothetically) malignant pleural mesothelioma (13 malignant pleural mesothelioma cell lines in comparison with the nontumorigenic mesothelial cell line MeT-5A) [This work] [93 ] rs758737644 -39c →t tgcactgtta c t acattctgtt 10 3 ↑ 4 10−3 rs549031146 -46t →a caaaacttat t a gggtgctatg 6 5 ↑ 4 10−3 ARNTL2 rs776246315 -21g →a, (t) ttccagccgc g a, (t) tgagtccagg 49 31 ↑ 8 10−6 (Hypothetically) inhibition of type 1 diabetes (murine model) [This work] [94 ] rs140915764 -22c →t tttccagccg c t gtgagtccag 49 32 ↑ 7 10−6 rs756988598 -23g →a gtttccagcc g a cgtgagtcca 49 39 ↑ 4 10−3 rs753093730 -33g →a, t ctgcccatag g a, t taaagtgttg 7 5 ↑ 3 10−3 rs536395877 -46c →a ttgttgtact c a tgctgcccat 7 5 ↑ 5 10−3 rs769981079 -42g →a, t ccagtgcatt g a, t ctcctgtggt 49 26 ↑ 12 10−6 rs111899732 -46c →t agaaccagtg c t attgctcctg 49 14 ↑ 18 10−6 rs746050396 -57g →a gttgagagag g a agaaccagtg 49 36 ↑ 5 10−6 ARNTL2 rs369143719 -48c →t tcttgttgta c t tctgctgccc 7 9 ↓ 4 10−3 (Hypothetically) suppression of diabetes protection (murine model) [This work] [95 ] rs374142420 -51g →c atgtcttgtt g c tactctgctg 7 10 ↓ 4 10−3 rs770635249 -56[ttg] DEL aataaatgtc ttg ttgtactctg 7 10 ↓ 4 10−3 CRY1 rs747100146 INS-49tt gataggagtt — tt aattatccta 6 7 ↓ 2 0.05 (Hypothetically) susceptibility to arthritis (CRY1 CRY2 knockout mice) [This work] [96 ] CRY2 rs753656899 -16a →g gcggggacta a g gggtggagtt 27 56 ↓ 12 10−6 (Hypothetically) susceptibility to arthritis and to mood disorders (CRY1 CRY2 and CRY2 knockout mice, resp.) [This work] [96 , 97 ] CRY2 rs575588903 -9a →g ctaagggtgg a g gttgcggcgt 27 25 ↑ 2 0.05 (Hypothetically) resistance to chemotherapy and poor prognosis in colorectal cancer (colorectal cancer samples) [This work] [98 ] rs757256843 -14g →t ggggactaag g t gtggagttgc 27 13 ↑ 10 10−6 rs760179689 -24g →a ccctgtgggc g a gggactaagg 27 22 ↑ 1 10−3 rs529410313 -47c →a agctgtcagt c a ttgcaagtca 22 18 ↑ 3 10−2 PER1 rs137890200 -17c →t gccaataagg c t ggagagtgtg 21 14 ↑ 6 10−6 (Hypothetically) longer survival among patients with gastric cancer [This work] [99 ] rs773740924 -26c →a ctcgccctgg c a caataaggcg 21 14 ↑ 7 10−6 rs2518024 -60g →a gtgctctgga g a ttaaaccagc 17 8 ↑ 12 10−6 PER1 rs796629786 -13t →g tcggcgcccc t g aagccaataa 56 118 ↓ 13 10−6 (Hypothetically) prostate cancer; ethanol hepatotoxicity, defects in hippocampal development, and resulting impairment of spatial learning capacity (PER1 knockout mice) [This work] [17 , 100 –103 ] rs3027175 -67c →t ccagcaggtg c t tctggagtta 17 19 ↓ 2 0.05 PER2 rs780846747 -20c →t cacaccttgt c t aagtagaaga 10 5 ↑ 12 10−6 (Hypothetically) susceptibility to acute Q fever in male patients; suppression of tumor growth (cell line S-180) [This work] [104 , 105 ] RORA rs750596430 -13c →t agccaggcag c t agcggcgcgg 106 60 ↑ 10 10−6 (Hypothetically) emphysema and its progression to lung cancer among smokers (mice, smoking machine TE-10) [This work] [106 ] rs535050458 -20c →t gccagcgagc c t aggcagcagc 106 72 ↑ 7 10−6 rs547170533 -21c →a , (t) cgccagcgag c a, (t) caggcagcag 106 72 ↑ 7 10−6 rs551503425 -50c →t tgccaatatc c t aagggttgcc 19 6 ↑ 15 10−6 rs374778785 -56a →t attatccccc a t tactcctccc 34 28 ↑ 4 10−3 RORA rs764749271 -28[12 bp] DEL ccttctcctt [12 bp] tttttttttt 28 31 ↓ 2 0.05 (Hypothetically) severe cerebellar ataxia (RORA knockout mice) [This work] [107 ] rs762440045 -55a →c acatggagtc a c gctccggcag 106 245 ↓ 15 10−6 RORC rs568650510 -15c →t actccttttc c t ctgcctgctg 55 25 ↑ 14 10−6 (Hypothetically) neurological manifestations of Behçet syndrome and asthma whose symptoms are circadian (worse at night) (18 patients and 30 pediatric patients, resp.) [This work] [51 , 108 , 109 ] CSNK1E rs777965060 -12c →t aggccctctg c t ttgaccccca 80 69 ↑ 3 0.05 (Hypothetically) higher risk of c-MYC-dependent carcinogenesis, testicular cancer, and overproduction of cerebral β -amyloid [This work] [110 –112 ] rs369188273 -16c →t ccctcccctc c t gcgcccgctc 288 195 ↑ 7 10−6 rs558609213 -18c →t tcttttcttg c t atccctgcag 30 9 ↑ 21 10−6 rs201914168 -20g →t cctgacagag g t ccctctgctt 80 53 ↑ 7 10−6 rs374953337 -25c →t tgacccctga c t agaggccctc 80 27 ↑ 17 10−6 rs368019196 -31c →t tgcctctgac c t cctgacagag 80 68 ↑ 3 10−2 rs775747363 -40[gcc] DEL ctggctgcct gcc tctgacccct 80 67 ↑ 4 10−3 rs780432736 -51g →a gccgggcgtg g a ctggctgcct 80 71 ↑ 2 0.05 rs747636670 -52g →a ggccgggcgt g a gctggctgcc 80 56 ↑ 5 10−6 CSNK1E rs775283367 -11c →g ctcttaccta c g gtcagctctt 8 10 ↓ 4 10−3 (Hypothetically) increased responsiveness to opioids (CSNK1E knockout mice) [This work] [113 ] rs746761879 -18t →c ccgactactc t c tacctacgtc 8 11 ↓ 5 10−6 rs777083641 -22[ag] DEL ctggctgcct ag tctgacccct 80 93 ↓ 3 10−2 rs2899302 -59g →c cgagaaaact g c cgcgaggcct 288 335 ↓ 3 10−2 CSNK1D rs4313857 (see Figure 1(b) ) -24g →a gccccgccgg g a ttgctagggg 57 32 ↑ 8 10−6 (Hypothetically) breast cancers (27 surgically resected tumor samples) [This work] [114 ] rs571866458 -38c →a gagccggacc c a gcagtagcgg 54 42 ↑ 4 10−3 rs540139460 -56g →a gcagggtcgg g a aggaggcctg 253 145 ↑ 10 10−6
