Polymorphisms in DNA Repair Gene XRCC3 and Susceptibility to Breast Cancer in Saudi Females

Table 4

Genotype and allele frequencies of studied SNPs in breast cancer patients and controls.

	Cancer (total = 143)	Control (total = 145)	Breast cancer versus control			value
	Number (%)	Number (%)	OR	95% CI
XRCC3 Thr241Met rs861539 C>T, genotype frequency
CC	43 (30.07)	32 (22.07)	Ref.
CT	73 (51.05)	78 (53.79)	0.7	0.4–1.25	1.41	0.236
TT	27 (18.89)	35 (24.14)	0.59	0.3–1.16	2.35	0.125
CT+TT	100 (69.93)	113 (77.93)	0.67	0.4–1.15	2.11	0.146
CT+CC	116 (81.11)	110 (75.86)	1.35	0.8–2.39	1.11	0.292
Alleles frequency
C	159 (55.59)	142 (48.97)	Ref.
T	127 (44.41)	148 (51.03)	0.77	0.6–1.08	2.29	0.1
XRCC3 rs1799794 A>G, genotype frequency
AA	102 (71.33)	93 (64.14)	Ref.
AG	40 (27.97)	28 (19.3)	1.3	0.7–2.28	0.86	0.353
GG	1 (0.007)	24 (16.55)	0.03	0.005–0.28	20.77	<0.0001
AG+GG	41 (28.67)	52 (35.86)	0.72	0.44–1.18	1.7	0.191
AA+AG	142 (99.3)	121 (83.44)	28.1	3.76–21.12	22.82	<0.0001
Alleles frequency
A	244 (85.33)	214 (73.74)	Ref.
G	42 (14.68)	76 (26.2)	0.48	0.32–0.74	11.73	<0.0001
XRCC3 rs1799796 A>G, genotype frequency
AA	59 (41.26)	61 (42.07)	Ref.
AG	53 (37.06)	55 (37.93)	0.99	0.59–1.67	0.00	0.988
GG	31 (21.67)	29 (20.0)	1.10	0.59–2.05	0.10	0.751
AG+GG	84 (58.74)	84 (57.9)	0.9	0.51–1.59	0.12	0.726
AA+AG	112 (78.32)	116 (80.0)	1.03	0.65–1.65	0.02	0.889
Alleles frequency
A	171 (59.79)	177 (61.03)	Ref.
G	115 (40.21)	113 (38.96)	1.05	0.75–1.47	0.09	0.76

OR = odds ratio; 95% CI = 95% confidence interval; = chi square. SNP = single nucleotide polymorphism; Ref.: reference.