Polymorphisms in DNA Repair Gene XRCC3 and Susceptibility to Breast Cancer in Saudi Females
Table 5
Comparison of the genotype and allele frequencies of the three SNPs in breast cancer patients, grouped on the basis of age of diagnosis, tumor grade, and ER and HER status (only results that have a statistically significant difference between the compared groups are shown).
Grouping parameter
Group
SNP statistics
Age of diagnosis rs1799796 (A>G) Genotype
<48 yrs frequency (%)
>48 yrs frequency (%)
OR
CI
value
AA
51.39
30.98
0.32
0.13–0.8
6.05
0.014
AG
33.33
40.84
2.03
0.95–4.3
3.42
0.06
GG
15.28
28.18
3.06
1.2–7.6
6.05
0.013
A
68.06
51.41
0.49
0.3–0.80
8.24
0.005
G
31.94
48.59
2.01
Tumour grade rs1799796 (A>G) Genotype
II frequency (%)
III frequency (%)
OR
CI
value
AA
35.71
56.82
5.66
1.47–21.8
7.29
0.007
AG
40.00
36.36
0.57
0.25–1.3
1.77
0.18
GG
24.29
6.82
0.17
0.05–0.68
7.29
0.007
A
55.71
75.00
2.38
1.32–4.29
8.64
0.003
G
44.29
25.00
0.41
ER status rs1799796 (A>G) Genotype
ER− frequency (%)
ER+ frequency (%)
OR
CI
value
AA
43.75
36.78
0.36
0.13–0.97
4.24
0.039
AG
41.70
36.78
1.35
0.63–2.88
0.60
0.44
GG
14.65
26.44
2.77
1.03–7.45
4.24
0.04
A
64.58
55.17
0.56
0.34–0.94
4.96
0.026
G
35.42
44.83
1.77
HER status rs1799796 (A>G) Genotype
HER− frequency (%)
HER+ frequency (%)
OR
CI
value
AA
47.89
33.80
0.29
0.11–0.75
6.91
0.009
AG
39.43
35.34
1.26
0.59–2.71
0.37
0.541
GG
12.68
30.88
3.45
1.3–8.8
6.91
0.009
A
67.61
51.47
0.51
0.31–0.83
7.52
0.006
G
32.39
48.53
1.96
OR = odds ratio; 95% CI = 95% confidence interval; = chi square. SNP = single nucleotide polymorphism.
