In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions
Table 1
Demographic and baseline clinical characteristics.
Healthy controls
Patients with CAD
Patients with CAD and T2DM
50
207
78
Age (y)
37.4 ± 1.4
58.3 ± 0.6
58.4 ± 1.1
Gender (male, %)
31 (62%)
124 (59.9%)
54 (69.2%)
Hypertension, (%)
0 (0)
114 (55.1%)
44 (56.4%)
Hyperlipidemia, (%)
0 (0)
120 (58.0%)
58 (66.7%)
Smoking, (%)
0 (0)
122 (58.9%)
47 (60.2%)
BMI (kg/m2)
24.0 ± 0.4
24.1 ± 0.2
25.2 ± 0.3
CG-GFR (mL/min)
92.1 ± 0.9
88.1 ± 0.7
85.4 ± 1.3
SBP (mmHg)
128.4 ± 1.8
131.3 ± 1.1
136.2 ± 2.3
DBP (mmHg)
73.5 ± 1.3
74.6 ± 0.7
74.8 ± 1.2
Heart rate (beats/min)
73.6 ± 1.3
74.4 ± 0.8
77.5 ± 1.4
LVEF (%)
63.2 ± 0.9
61.8 ± 0.5
58.8 ± 0.9
Fasting blood glucose (mmol/L)
5.3 ± 0.3
5.5 ± 0.4
7.2 ± 0.3
HbA1C (%)
5.2 ± 0.3
5.4 ± 0.2
6.9 ± 0.4
Duration of diabetes (years)
0
0
3.4 ± 1.1
Drug therapy
Antiplatelet drugs, (%)
0 (0)
133 (64.3%)
51 (65.4%)
Beta-blocker, (%)
0 (0)
78 (37.7%)
30 (38.5%)
ACEI/ARB, (%)
0 (0)
94 (45.4%)
36 (46.2%)
Statins, (%)
0 (0)
127 (61.4%)
42 (53.8%)
Diuretics, (%)
0 (0)
26 (12.6%)
9 (11.5%)
CCB, (%)
0 (0)
103 (49.8%)
38 (48.7%)
Insulin, (%)
0 (0)
0 (0)
17 (21.8%)
BMI: body mass index; CG-GFR: Cockcroft-Gault glomerular filtration rate; SBP: systolic blood pressure; DBP: diastolic blood pressure; LVEF: left ventricular ejection fraction; HbA1C: glycosylated hemoglobin; IL-2: interleukin-2; hs-CRP: high-sensitivity C-reactive protein; TNF-α: tumor necrosis factor-α; MCP-1: monocyte chemotactic protein-1; ACEI: angiotensin converting enzyme inhibitor; ARB: angiotensin II receptor blocker; CCB: calcium channel blocker. versus CAD patients with diabetes; versus CAD patients with diabetes.
