Ultrastructural Mapping of the Zebrafish Gastrointestinal System as a Basis for Experimental Drug Studies

Figure 2

Parasagittal section of a 12 dpf ZF larvae stained with toluidine blue and imaged with light microscopy, showing the different components of the digestive system (c). Corresponding EM images of the different regions include the oesophageal area, rich in goblet cells (Gob) (a), the pancreas, with a pancreatic duct (PD) in the middle and surrounded by acinar cells (Aci) rich in zymogen granules (b). The liver and its hepatocytes (Hep) surrounded by sinusoids (Sin) and its network of bile ducts are shown in (d), as well as the intestine lined with enterocytes (Ent) rich in villi forming the intestinal brush border (BB) in (e). (SB) is the swim bladder. Scale bar = 20 μm (LM) and 5 μm (EM).